High-Quality eCOA Clinical Trial Examples by Therapy Area
  Therapy area |
 Indication |
 Examples |
|---|---|---|
| Cardiovascular / Endocrinology |
Diabetes | Continuous glucose monitoring and activity tracking with real-time symptom reporting and patient reported outcomes across 6 countries |
|
Diabetes |
Web-based patient data capture for medical device study | |
| Heart Failure | Symptom and questionnaire data capture correlated with medical device data for heart failure occurrence post hospital discharge | |
| CNS |
Epilepsy | Major phase III study capturing daily seizure diaries with adjudication, entered by multiple caregivers |
| Major Depressive Disorder | Multiple studies capturing ePRO and ClinRO data captured both at-site and at participant’s homes | |
| ALS (Motor Neurone Disease) | Study capturing essential ePRO / ObvsRO across multiple countries | |
| Parkinson’s | 4,200 participant direct-to-patient study capturing eConsent, ePRO, symptom, eDiary an wearable device data | |
| Parkinson’s | Phase IV study capturing ePRO, symptom and eDiary data through participants’ own devices | |
| Multiple Sclerosis | Hospital-led patient and PRO capture program, supported by Top 20 pharma | |
|
Dermatology |
Erythropoietic protoporphyria (EPP) | Capture of sunlight exposure, prodromal symptoms, and attack diaries, with complex overlapping time edit checks |
| Genital Psoriasis | Study across multiple countries, using uMotif to capture key ePRO / eDiary data | |
| Atopic Dermatitis | Site and home-based ePRO data capture | |
|
Gastroenterology |
Ulcerative Colitis | Study to assess treatment effectiveness |
| Celiac Disease | Natural history study into signs and symptoms | |
| Immunology and Inflammation |
Chronic Pain | 13,500 participant direct-to patient study into the link between weather and pain including fibromyalgia, RA and OA |
| Rheumatoid Arthritis | Fully remote DCT capturing ePRO and home blood sample collection | |
| Rheumatoid Arthritis | Virtual study exploring impact of sleep through capture of symptoms, validated questionnaires, and wearable device actigraphy data | |
|
Ankylosing Spondylitis |
Hospital-led program involving patients capturing PROs, device and other data through their own devices | |
| Oncology |
Melanoma | Multi-year registry study engaging participants in regular ePRO data capture |
| Metastatic Cholangiocarcinoma |
Capture of ePRO data alongside treatment cycles | |
| Glioblastoma | Patient-led movement allowing patients with GBM to track symptoms to help accelerate new treatments to market | |
| Colorectal Cancer | ePRO captured at home and on-site, across multiple treatment cycles | |
| Pain |
Pain | Phase IV study in chronic pain with daily and weekly ePRO capture, alongside wearable device |
| Women’s Health | Pivotal study in >30 countries including China with a pain primary endpoint | |
| Oncology | Capture of pain levels and changes during treatment regime across multiple cancer types | |
| Rare disease |
Dravet Syndrome | Observational study investigating caregiver burden for children with Dravet Syndrome |
| Congenital Adrenal Hyperplasia | ePRO data capture for key effectiveness study | |
| Hemophilia | Multi-study Phase IV and Observational program across 26 countries | |
| Respiratory / Allergy |
Asthma | Symptom tracking study to show subtle differences in patient quality of life captured through unique ‘motif’ interface |
| COVID-19 | Virtual study exploring effectiveness of sinus wash to reduce transmission of COVID-19 |
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