High-Quality eCOA Clinical Trial Examples by Therapy Area



Therapy area


Indication


Examples
Cardiovascular / Endocrinology
Diabetes Continuous glucose monitoring and activity tracking with real-time symptom reporting and patient reported outcomes across 6 countries

Diabetes

Web-based patient data capture for medical device study
Heart Failure Symptom and questionnaire data capture correlated with medical device data for heart failure occurrence post hospital discharge
CNS
Epilepsy  Major phase III study capturing daily seizure diaries with adjudication, entered by multiple caregivers 
Major Depressive Disorder    Multiple studies capturing ePRO and ClinRO data captured both at-site and at participant’s homes 
ALS (Motor Neurone Disease)  Study capturing essential ePRO / ObvsRO across multiple countries 
Parkinson’s 4,200 participant direct-to-patient study capturing eConsent, ePRO, symptom, eDiary an wearable device data
Parkinson’s Phase IV study capturing ePRO, symptom and eDiary data through participants’ own devices
Multiple Sclerosis Hospital-led patient and PRO capture program, supported by Top 20 pharma

Dermatology

Erythropoietic protoporphyria (EPP)  Capture of sunlight exposure, prodromal symptoms, and attack diaries, with complex overlapping time edit checks 
Genital Psoriasis  Study across multiple countries, using uMotif to capture key ePRO / eDiary data 
Atopic Dermatitis  Site and home-based ePRO data capture 

Gastroenterology

Ulcerative Colitis Study to assess treatment effectiveness
Celiac Disease Natural history study into signs and symptoms
Immunology and Inflammation
Chronic Pain 13,500 participant direct-to patient study into the link between weather and pain including fibromyalgia, RA and OA
Rheumatoid Arthritis Fully remote DCT capturing ePRO and home blood sample collection
Rheumatoid Arthritis Virtual study exploring impact of sleep through capture of symptoms, validated questionnaires, and wearable device actigraphy data

Ankylosing Spondylitis

Hospital-led program involving patients capturing PROs, device and other data through their own devices
Oncology
Melanoma Multi-year registry study engaging participants in regular ePRO data capture
Metastatic
Cholangiocarcinoma
Capture of ePRO data alongside treatment cycles
Glioblastoma Patient-led movement allowing patients with GBM to track symptoms to help accelerate new treatments to market
Colorectal Cancer  ePRO captured at home and on-site, across multiple treatment cycles 
Pain
Pain Phase IV study in chronic pain with daily and weekly ePRO capture, alongside wearable device
Women’s Health Pivotal study in >30 countries including China with a pain primary endpoint
Oncology Capture of pain levels and changes during treatment regime across multiple cancer types
Rare disease
Dravet Syndrome Observational study investigating caregiver burden for children with Dravet Syndrome
Congenital Adrenal Hyperplasia ePRO data capture for key effectiveness study
Hemophilia Multi-study Phase IV and Observational program across 26 countries
Respiratory / Allergy
Asthma Symptom tracking study to show subtle differences in patient quality of life captured through unique ‘motif’ interface
COVID-19 Virtual study exploring effectiveness of sinus wash to reduce transmission of COVID-19

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